Influence of solvent on antimicrobial activity of Carlinae radix essential oil and decoct

摘要

Jovi?, J., Mihajilov-Krstev T., ?abar A., Stojanovi?-Radi? Z.: Influence of solvent on antimicrobial activity of Carlinae radix essential oil and decoct. Biologica Nyssana, 3 (2), December 2012: 61-67. Plants of the family Asteraceae are known for their use in ethnopharmacology, available as commercial drugs. In this study, antimicrobial activity of Carlinae radix commercial drug’s vinegar decoction and essential oil, dissolved in various solvents (ETOH- ethanol, DMSO- dimethyl sulfoxide and Tween 80- polyoxyethylene sorbitan monolaurate) was tested to investigate the effect of solvents on activity and to compare the results with previous researches. The microdilution method was used to determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). The results showed that antimicrobial activity of the Carlinae radix oil significantly depends on the solvent and that most efficient antimicrobial effect had the essential oil dissolved in 7% ethanol, which points to significant synergistic effect of the oil with this solvent.