Changes in lipid profile of rat plasma after chronic administration of Astavarga Kvatha Curna (AST) - an Ayurvedic formulation

摘要

The aim of the present study was to observe changes in the lipid profile parameters of rat plasma after chronic administration of Astavarga Kvatha Curna (AST) which is used in the treatment of vata roga (neurological diseases) in Bangladesh. The animals used for this research work were albino rats (Rattus novergicus: Sprague- Dawley strain) and AST was administered per oral route at a dose of 100ml/kg body weight, once daily, up to 41 days for all the experiments. Forty rats, equally of both sexes, were randomly grouped into four where one male and one female group were used as control and other groups were used as test. In case of male rats, administration of AST decreased all the lipid profile parameters (triglycerides, total cholesterol, LDL and HDL) except VLDL with p values of p=0.892, p=0.787, p=0.754, p=0.682 respectively. Similar trend in the result was observed in case of female rats. Triglycerides (p=0.605), total cholesterol (p=0.953), LDL (p=0.811) and HDL (p=0.836) were decreased in comparison with the control group. On the contrary, VLDL was increased with p value of p=0.739. The observed alteration in lipid profile parameters in both male and female rats was not statistically significant.