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首页> 外文期刊>Current Molecular Medicine >Gene Profiles within the Adult Subventricular Zone Niche:Proliferation, Differentiation and Migration of Neural Progenitor Cells in the Ischemic Brain
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Gene Profiles within the Adult Subventricular Zone Niche:Proliferation, Differentiation and Migration of Neural Progenitor Cells in the Ischemic Brain

机译:成人脑室下区利基内的基因概况:缺血性脑神经祖细胞的增殖,分化和迁移。

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摘要

Focal cerebral ischemia induces neurogenesis in the subventricular zone (SVZ) of the adult human brain. Neurogenesis is controlled by proliferation, differentiation, and migration of neural progenitor cells. This article reviews emerging data that changes of cell cycle kinetics of neural progenitor cells induced by stroke contribute to increased neural progenitor cell proliferation and that gene profiles control proliferation, differentiation, and migration of neural progenitor cells within the SVZ niche. A better understanding of gene profiles that control the biological function of adult SVZ neural progenitor cells could lead to more selective and effective treatments to enhance neurogenesis during stroke recovery.
机译:局灶性脑缺血在成年人脑的脑室下区域(SVZ)中诱导神经发生。神经发生受神经祖细胞的增殖,分化和迁移控制。本文回顾了新兴数据,这些数据表明,中风引起的神经祖细胞的细胞周期动力学变化有助于神经祖细胞的增殖,而基因谱控制着SVZ生态位内神经祖细胞的增殖,分化和迁移。对控制成年SVZ神经祖细胞生物学功能的基因谱的更好理解可能会导致更选择性和有效的治疗,以增强中风恢复过程中的神经发生。

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