Advances in Marine Natural Products of the Indole and Annelated Indole Series: Chemical and Biological Aspects

摘要

Marine natural products, form a field of scientific endeavour, that has recentlyngrown considerably. The isolation, biological evaluation, chemical properties andnsynthetic elaborations of products of marine organisms have attracted the attention ofnorganic chemists, medicinal chemists, biologists and pharmacists. In this context anstructurally and biologically highly interesting class is represented by the marinennatural products containing an indole moiety in a pure substituted form or in an anella-nted form. The present review summarizes primarily the actual results concerning these products as newnpharmacologically attractive lead compounds for drug design. The chemistry, biological evaluation andnsynthetic aspects are discussed. The spectrum of compounds represented comprises simply substitutednindoles, peptidic products, dimeric indoles, anellated indoles and a variety of carbazoles. Most of them exhibitnsignificant cytotoxicities.