DNA-binding Antitumor Agents: from Pyrimido[5,6,1-de]acridines to Other Intriguing Classes of Acridine Derivatives

摘要

In the field of antitumor DNA-binding agents, the class of acridine derivativesnplay an important role either as number of compounds or as importance of theirnanticancer properties. We have synthesized a number of acridine derivatives as potentialnantitumor drugs, in which the chromophore is fully or partially constituted by acridinenor by 9-acridone ring systems: from the pyrimido[5,6,1-de]acridines, to thenpyrimido[4,5,6-kl]acridines, the bis(amine-functionalized) 9-acridone-4-carboxamides,nthe bis(amine-functionalized) acridine-4-carboxamides, and the pyrazolo[3,4,5-nkl]acridine-5-carboxamides. In the present revue we will describe the rational design, thensynthesis, and the salient biological characteristics of these classes of acridinenderivatives.