10-20Joules as a Neuromolecular Quantum in Medicinal Chemistry: An Alternative Approach to Myriad Molecular Pathways?

摘要

The myriads of molecular pathways that have been measured to understand the physical bases of neuronal and nother cellular functions have exceeded classical comprehension. In the tradition of Bohr and Schrodinger, the hypothesis nis developed that molecular pathways are simply epiphenomenal transports of quanta with increments in the order of 10-20n nJ. Experimental measurements of photon emissions from cell cultures and the serial steps of phosphorylation in general nmolecular pathways and transformations in chromophores supported this contention. This discrete value is also associated nwith action potentials, intersynaptic events, the biophysical bases of membrane potentials, the numbers of action potentials nper cell from magnetic energy potential, and the interionic distances around membranes. Consideration of information as ndiscrete increments of energy may allow greater experimental control and external intervention of pathways relevant to nmedicinal chemistry.