Preface [Hot Topic: Cellular Targets for Anti-Cancer Therapy (Guest Editor: Alexander A. Shtil)]

摘要

This issue of CURRENT DRUG TARGETS is focused on cancer therapy, one of the most challenging problems for humanity. Indeed, this problem represents the nexus of life science with many other disciplines. Outburst of modern biology uncovers the fundamental mechanisms of single cell behavior (e.g., gene expression regulation, macromolecular biosynthesis and transport, cell cycle progression, division, death) which, in turn, sets stage for understanding tumor cell-organism interactions such as control of differentiation, clonal proliferation, evasion from surveillance, to mention a few major paradigms of cancer biology. This basic knowledge needs to be translated into therapeutically applicable strategies, a task for unified efforts of biologists and medical doctors with pharmacologists, physico-chemists, medicinal chemists.