Advanced Glycation End Products (AGEs) and Diabetic Vascular Complications

摘要

Diabetic vascular complication is a leading cause of acquired blindness, end-stage renal failure, a variety ofnneuropathies and accelerated atherosclerosis, which could account for disabilities and high mortality rates in patients withndiabetes. Chronic hyperglycemia is essentially involved in the development and progression of diabetic micro- andnmacroangiopathy. Among various metabolic derangements implicated in the pathogenesis of diabetic vascularncomplication, advanced glycation end product (AGE) hypothesis is most compatible with the theory of ‘hyperglycemicnmemory’. In this review, we discuss the molecular mechanisms of diabetic vascular complication, specially focusing onnAGEs and their receptor (RAGE) system. Several types of AGE inhibitors and their therapeutic implications in thisndevastating disorder are also discussed here.