Cytogenetic Effects of Met-enkephalin (Peptid-M) on Human Lymphocytes

摘要

The structure, complementary structure and cytogenetic/prolifera- tive effects of the Met-enkephalin on human peripheral blood lym- phocytes were analyzed. Met-enkephalin, i.e. Peptid-M (LUPEX~R), is a low molecular weight synthetic pentapeptide that corresponds to thymus Met-enkephalin. Its structure was examined by means of NMR spectroscopy. The influence of Met-enkephalin on in vitro normalization of chromosomally aberrant lymphocytes of patients suffering from different immune-mediated diseases, was analyzed by the sensitive cytogenetic tests for screening and detection of ge- nome damages in human lymphocytes.