Platinum complexes containing adenine-based ligands: An overview of selected structural features

摘要

This work offers an overview of the platinum(II,IV) complexes involving adenine or its derivatives coordinated to platinum through N- or C-donor atom(s) of the adenine moiety. This large group of coordination compounds is reviewed with respect to the oxidation state of the platinum central atom(s), the nuclearity of the complexes and the coordination mode(s) of the adenine-based ligands. The important structural features, such as selected bond lengths and angles in the vicinity of the platinum atom as well as those around the adenine coordination sites, are summarized for a total of 122 crystallographically characterized complexes. Among them, complexes containing monodentate N7-coordinating adenine based ligand(s) are the most numerous, while the monodentate N6-, N9- or C8- and bidentate N1,N6-coordination modes are rare. Numerous adducts of the platinum complexes with nucleotides, nucleosides and nucleic acids coordinated to the metal center through the adenine moiety are also discussed. The review of the structural features of platinum complexes with adenine-based ligands is completed with a brief summary of the biological activities of the complexes known to date. (C) 2016 Elsevier B.V. All rights reserved.