Assessing associations in substance use across three generations: from grandparents to sons and from sons to their children

摘要

The Three Generational Study (3GS) began in the early 1990s and involves the third generation (G3) offspring of second generation (G2) fathers who were originally recruited in 1984 as part of the Oregon Youth Study (OYS) in mid-childhood (ages 9-10 years) along with their first-generation (G1) parents. As boys, the G2 fathers lived in higher delinquency neighbourhoods of a medium-sized Pacific Northwestern United States city. The 0YS-3GS examines questions concerning socially mediated intergenerational transmission versus discontinuity (or moderation) of antisocial behaviour, substance use and related problem behaviours. Questions address influences of the grandparents, or Generation 1 (G1), on their sons in G2 and in turn of these sons and their partners on their own children in G3. In this article, we present an overview of the study design - and underlying theory - related to general and outcome-specific transmission pathways. We then summarise key issues and findings to date related to the current main focus of the study regarding the intergenerational associations in substance use.