Comparative End-to-End Analysis of Ca2+-Signaling-Based Molecular Communication in Biological Tissues

摘要

Calcium (Ca)-signaling-based molecular communication is a short-range communication process that diffuses and propagates ions between the cells of a tissue. The communication process is initiated via stimulation and amplification of the production of Ca ions within a cell; these ions then diffuse through a physical connection between cells called a gap junction. Ca signaling can be found in different classes of cell. In cells, initiation of the Ca-signaling process is accompanied by an electrical component; for cell types, the electrical component is absent; while cells exhibit both behaviors. This paper provides a comparison and analysis of the communication behavior in tissues comprised three specific cell types that utilize Ca signaling: (nonexcitable), (excitable), and (hybrid). The analysis focuses on spatiotemporal Ca concentration dynamics and how they are influenced by the intracellular signaling process, the molecular diffusion delay, the gain and capacity of the communication channel, as well as intracellular signaling interference. This analysis of the communication behavior in the context of tissues provides insights useful for, , the design of nanomachines that are situated within tissues and that use analysis of the communication channel to infer tissue health.