Frontal polymerization synthesis and drug delivery behavior of thermo-responsive poly(N-isopropylacrylamide) hydrogel

摘要

Thermo-responsive hydrogels of poly(N-isopropylacrylamide) (PNIPAm) were prepared by fontal polymerization and investigated as a temperature-triggered delivery device for the model drug aspirin. The influence of relative amount of reactant components on the feature of the polymerization front was studied. Furthermore, aspirin was loaded into hydrogels prepared by fontal polymerization method and classical polymerization, respectively, and its release characteristics were determined under different temperature conditions (25 °C and 37 °C). The drug storages and kinetic parameters for two hydrogels indicated that drug-loading capacity and drug release of frontal polymerization (FP) hydrogel were improved as compared with the classical polymerization (CP) one. Scanning electronic microscope and differential scanning calorimetry (DSC) results could account for these improvements in drug delivery for FP hydrogel. The above results indicate that FP can be an alternative method for the preparation of PNIPAm hydrogels used as drug delivery devices with less time consuming and easier protocols.