Stimuli-responsive behavior of complex micelles based on double hydrophilic block copolymer and fluorescent indicator

摘要

The double hydrophilic block copolymer poly(ethylene glycol mono-methyl ether)-block-poly(4-vinylpyridine) (mPEG43-b-P4VP115) was synthesized by atom transfer radical polymerization. The structure, molecular weight and molecular weight distribution of mPEG43-b-P4VP115 were characterized by 1H-NMR and gel permeation chromatography combined with laser light scattering technique. The complex micelles based on mPEG43-b-P4VP115 and the disodium 2-naphthol-3,6-disulfonate were obtained in acid aqueous solution. The morphologies of the complex micelles were observed by transmission electron microscopy. The revertible temperature and pH-responsive behaviors of complex micelles were studied by dynamic light scattering and fluorescence techniques.