Lipoprotein-associated phospholipase A<sub>2</sub> for early risk stratification in patients with suspected acute coronary syndrome: a multi-marker approach

M. M?ckel; Reinhold Müller; J?rn O. Vollert; Christian Müller; Oilver Danne; Ragnar Gareis; Thomas St?rk; Rainer Dietz; Wolfgang Koenig

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Lipoprotein-associated phospholipase A₂ for early risk stratification in patients with suspected acute coronary syndrome: a multi-marker approach

机译：脂蛋白相关磷脂酶A _{2 用于疑似急性冠脉综合征的早期危险分层：一种多标记方法}

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Aims Numerous markers have been identified as useful predictors of major adverse cardiac events (MACE) in patients with suspected acute coronary syndrome (ACS). However, only little is known about the relative benefit of the single markers in risk stratification and the best combination for optimising prognostic power. The aim of the present study was to define the role of the emerging cardiovascular risk marker lipoprotein-associated phospholipase A₂ (Lp-PLA₂) in a multi-marker approach in combination with troponin I (TnI), NT-proBNP, high sensitivity (hs)CRP, and D-dimer in patients with ACS.

机译：目的已经确定了许多标记物，可用于可疑急性冠脉综合征（ACS）患者主要不良心脏事件（MACE）的有用预测指标。但是，关于单一标志物在风险分层中的相对益处以及优化预后能力的最佳组合知之甚少。本研究的目的是确定新兴的心血管危险标志物脂蛋白相关磷脂酶A _{2 （Lp-PLA _{2 ）在多标志物方法中的作用。与肌钙蛋白I（TnI），NT-proBNP，高敏感性（hs）CRP和D-二聚体联合用于ACS患者。}}

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《Clinical Research in Cardiology》 |2007年第9期|604-612|共9页
作者
M. M?ckel; Reinhold Müller; J?rn O. Vollert; Christian Müller; Oilver Danne; Ragnar Gareis; Thomas St?rk; Rainer Dietz; Wolfgang Koenig;
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作者单位

Dept. of Cardiology, Charité – University Medicine Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany;

James Cook University, School of Public Health/Tropical Medicine, Townsville, Australia;

Dept. of Cardiology, Charité – University Medicine Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany;

Institute for Clinical Chemistry Charité – Universit?tsmedizin Berlin, Campus Virchow-Klinikum, Berlin, Germany;

Dpt. of Nephrology/Intensive, Care Medicine Charité – Universit?tsmedizin Berlin, Campus Virchow-Klinikum, Berlin, Germany;

Angiology and Internal Intensive, Care Medicine, Karl Olga Krankenhaus, Stuttgart, Germany;

Angiology and Internal Intensive, Care Medicine, Karl Olga Krankenhaus, Stuttgart, Germany;

Dept. of Cardiology, Charité – University Medicine Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany;

Dept. of Internal Medicine II-Cardiology, University of Ulm Medical Center, Ulm, Germany;

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关键词
acute coronary syndrome; troponin I; NT; proBNP; LP; PLAsub2/sub; emergency room; CART; analysis;

机译：急性冠状动脉综合征;肌钙蛋白I;NT;proBNP;LP;PLA sub 2 / sub;急救室;CART分析;

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1. The Prognostic Value of Lipoprotein-Associated Phospholipase A 2 in the Long-Term Care of Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention [J] . Lijiao Yang, Hong Wang, Yida Zhang, Clinical and applied thrombosis/hemostasis : . 2018,第5期

机译：脂蛋白相关的磷脂酶A 2在经皮冠状动脉介入治疗的急性冠脉综合征患者的长期护理中的预后价值
2. The Prognostic Value of Lipoprotein-Associated Phospholipase A(2) in the Long-Term Care of Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention [J] . Yang Lijiao, Wang Hong, Zhang Yida, Clinical and applied thrombosis/hemostasis . 2018,第5期

机译：脂蛋白相关磷脂酶A（2）在经皮冠状动脉介入的急性冠状动脉综合征患者长期护理中的预后价值
3. Decreased circulating lipoprotein-associated phospholipase A2 levels are associated with coronary plaque regression in patients with acute coronary syndrome [J] . DohiT., MiyauchiK., OkazakiS., Atherosclerosis . 2011,第2期

机译：急性冠状动脉综合征患者循环脂蛋白相关磷脂酶A2水平降低与冠状动脉斑块消退相关
4. The importance of the charlson index in risk stratification in patients admitted for acute coronary syndrome without st-segment elevation [C] . Ramirez Marrero, Gaitan Roman, Jimenez Navarro, International Conference on Pre-hypertension Cardio Metabolic Syndrome . 2011

机译：Charlson指数在没有ST段高度的患者患者中患者风险分层的重要性
5. Factors Associated with Delayed Pre-Hospital Time in Patients with Suspected Acute Coronary Syndrome: Effect of Gender. [D] . Contreras, Johanna Paola. 2010

机译：疑似急性冠脉综合征患者院前时间延迟的相关因素：性别影响。
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Lipoprotein-associated phospholipase A2 for early risk stratification in patients with suspected acute coronary syndrome: a multi-marker approach

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Lipoprotein-associated phospholipase A₂ for early risk stratification in patients with suspected acute coronary syndrome: a multi-marker approach