Physical activity increases bone formation and decreases bone resorp on as assessed by biochemical markers of bone turnover

摘要

Physical activity (PA) is considered an important factor in attaining bone mass and an essential part of any anti-osteoporotic treatment. The present study investigated the effect of PA on markers of bone turnover in a) 220 healthy females and 278 healthy males from a cross-sectional population survey and b) 22 healthy young male volunteers during a nine weeks course of aerobic (n= 11) and anaerobic training (n= 11). Serum bone alkaline phosphatase (BAP; by IRMA), osteocalcin (OC, by LIA) and urinary total pyridinium crosslinks (PYD, DPD; by HPLC) were determined. In the cross-sectional study, subjects on regular PA had lower urinary crosslinks as marker of bone resorption than sedentary subjects. On the bone formation side, serum BAP, but not serum OC levels were elevated in physical active subjects. Bone density showed a trend towards higher values in the active groups, but no significant changes were found. In the longitudinal study, aerobic training resulted in a decrease of PYD and DPD (p < .001 and p < .05, resp.) and in a temporary suppression of BAP and OC. Anaerobic PA was associated with a continuous increase in BAP, OC and crosslink excretion. Conclusion: Regular and aerobic PA lead to changes in bone turnover compatibel with decreased bone resorption and increased bone formation. However, earliest changes are seen on the bone resorption side. On the other hand, anaerobic training seems to result in a parallel increase of both sides of bone turnover.