Don't Resist Using U-500 Insulin and Pramlintide for Severe Insulin Resistance

摘要

Specifically, it: * Slows stomach emptying so that glucose excursions from meals more closely match the peak of U-500 insulin, about 2-3 hours after injection, * Suppresses glucagon and, therefore, hepatic glucose production after meals and, in turn, improves postmeal glucose levels, and * Helps patients by increasing satiety so they are able to eat less, which can reduce weight gain or promote weight loss. Continued Emphasis on Lifestyle Modification Because weight gain is a common problem with insulin use in general and especially when improving control, it is important to continue working with people with insulin resistance on lifestyle modifications related to meal planning, portion control, and physical activity. Show less