C-Reactive Protein: Eighty Years from Discovery to Emergence as a Major Risk Marker for Cardiovascular Disease

摘要

Notable among these reports were data from Frederick de Beer, Brad Berk, and Wayne Alexander (16, 17), who described increased CRP concentrations among patients with "active" coronary disease, as well as highly influential studies from Attilio Maseri, Giovanna Liuzzo, Luigi Biasucci, and Frits Haverkate (18, 19), in which increased concentrations of CRP were again observed among those with unstable angina or chronic atherothrombotic disease. Because concentrations of CRP increase after myocardial ischemia, however, these studies of individuals with known vascular disease were not informative regarding the key question of whether CRP concentrations are increased in advance of disease expression.