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机译:母体血浆DNA分析与结扎大规模平行测序的21三体性无创产前诊断。
Rossa W.K. Chiu,1,2 Hao Sun,1,2 Ranjit Akolekar,3 Christopher Clouser,4 Clarence Lee,4 Kevin McKernan, 4 Daixing Zhou,4 Kypros H. Nicolaides,3 and Y.M. Dennis Lo1,2*1 Centre for Research into Circulating Fetal Nucleic Acids, Li Ka Shing Institute of Health Sciences, and 2 Department of Chemical Pathology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China, 3 Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London, UK, 4 Life Technologies, Beverly, MA, * address correspondence to this author at: Department of Chemical Pathology, The Chinese University of Hong Kong, Rm. 38061, 1/F, Clinical Sciences Bldg., Prince of Wales Hospital, 30-32 Ngan Shing St., Shatin, Hong Kong SAR, China. Fax 852-2636-5090, e-mail loym@cuhk.edu.hk.Author Contributions: All authors confirmed they have contributed to the intellectual content of this paper and have met the following 3 requirements: (a) significant contributions to the conception and design, acquisition of data, or analysis and interpretation of data, (b) drafting or revising the article for intellectual content, and (c) final approval of the published article.Authors' Disclosures of Potential Conflicts of Interest: Upon manuscript submission, all authors completed the Disclosures of Potential Conflict of Interest form. Potential conflicts of interest:Employment or Leadership: None declared.Consultant or Advisory Role: Y.M.D. Lo, Sequenom.Stock Ownership: C. Lee, Life Technologies, K. McKernan, Life Technologies, D. Zhou, Life Technologies, Y.M.D. Lo, Sequenom. Honoraria: None declared.Research Funding: R.W.K. Chiu and Y.M.D. Lo, Life Technologies, sponsor of the sequencing runs as part of a grant from the Innovation and Technology Fund (ITS/054/09), Y.M.D. Lo, Sequenom.Expert Testimony: None declared.Other Remuneration: R.W.K. Chiu and Y.M.D. Lo hold patents and have filed patent applications on the detection of fetal nucleic acids in maternal plasma for noninvasive prenatal diagnosis. Y.M.D. Lo was supported by an endowed professorship from the Li Ka Shing Foundation.Role of Sponsor: The funding organizations played no role in the design of study, choice of enrolled patients, review and interpretation of data, or preparation or approval of manuscript.Acknowledgments: We thank Elizabeth Levandowsky and Tristen Weaver for preparing the libraries and performing the sequencing.,;
机译:母体血浆DNA分析通过连接进行大规模平行测序,用于21三体性的无创产前诊断。
机译:母体血浆DNA分析与结扎大规模平行测序的21三体性无创产前诊断。
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