The α2C-adrenoceptor deletion322–325 variant and cold-induced vasoconstriction

摘要

Cold-induced vasoconstriction is mediated in part by selective enhancement of local α2C-adrenoceptor (α2C-AR) activity. A common insertion–deletion variant in the α2C-AR gene (ADRA2C del322–325) results in an approximately 85% reduction of agonist-mediated function in vitro. We tested the hypothesis that individuals with the ADRA2C del322–325 variant have attenuated vasoconstriction in response to cold.