Excitatory amino acids in cerebrospinal fluid and their relations with clinical features and outcomes in acute head injury

摘要

Conclusion The content of EAAs in CSF in- creases following acute head injury and remains higher at least a week post-injury in severely injured patients. The more sever the trauma, the more obvious the excitotoxicity induced by EAAs; the more serious the secondary brain insult an the brain edema will be, the worse the outcome, naturally. Objective To determine the contents and dy- namics of excitatory amino acids (EAAs), glutamate (GLU) and aspartate (ASP) in the cerebrospinal fluid (CSF) of patents with acute head injury and to clarify the relationship of EAAs with clinical feature s and outcomes.