Brief reports: Opening blood-brain-barrier by intracarotid infusion of papaverine in treatment of malignant cerebral glioma

摘要

Conclusion The combined chemotherapy with papaverine and BCNU through intra-arterial infusion is simple, safe and effective in treating malignant cerebral glioma so ling as the tumor is sensitive to the drugs. Objective To find an effective method for the Treatment of malignant cerebral glioma by opening the Blood-barrier (BBB). Method The concentration of methotrexate (MTX) in tumor was measured in 18 patients with cerebral glioma, and 155 patients with malignant glioma were treated by intracarotid infusion of papaver- ine and is-chloronitrosourea (BCNU).