Alpha-1 adrenergic receptors in liver plasma membranes of cirrhotic patients with portal hypertension: a quantitative study

摘要

Conclusions The decreased concentration and affinity of plah-1 adrenergic receptors may play an im- portant role in the metabolic disturbances of cate- chloamines often seen in some cirrhotic patients, and have implications in the pathogenesis of portal hyper- tension. Objective To investigate the changes of alpha-1 adrenergic receptors in cirrhotic liver and the relaion- Ship between the changes and the pathogenesis of por- Tal hypertension. Methods The concentration and affinity of aplpha-1 adrenergic receptors in the liver plasma mem- branes of posthepatitic cirrhotic patients with porthal hy- pretension were quantitatively measured using radioli- gand binding analysis.