Cellular composition and anatomic distribution in nonfunctioning pancreatic endocrine tumors: immunohistochemical study of 30 cases

摘要

Conclusions Immunohistochemically, the high positive rate to peptide hormones suggest that the nonfunctioning pancreatic endocrine tumors are actually no nonfunctioning; they are asymptomatic pancreatic endocrine tumors. Moreover, an uneven distribution of positive endocrine cells in the nonfunctioning pancreas endocrine tumors within the pancreas was identified. Objective To investigate the cytological pattern and distribution in nonfunctioning pancreatic endocrine tumors. Methods Using labeled streptavidin-biotin (LSAB), immunohistochemical staining for insulin. glucagons, somatostatin, pancreatic polypeptide and gastrin was performed on 30 nonfunctioning pancreatic endocrine tumors form 30 patients. The cellular com- positon and anatomic distribution in these tumors were analyzed.