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Down-regulation of PTH/PTHrP receptor in the kidney of patients with renal impairment

机译:肾功能不全患者肾脏中PTH / PTHrP受体的下调

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摘要

Conclusion The down-regulation of renal PTH/ PTHrP receptor mRNA occurs much earlier than the changes of renal function, plasma PTH, serum phos- phorus and calcium in the course of human renal disease. Objective To investigate whether the down- Regulation of renal parathyroid hormone/parathyroid hormone related protein (PTH/PTHrP) receptor mes- senger ribonucleic acid (mRNA) expression is a gener- al phenomenon in patients with different stages of renal disease, besides chronic renal failure.
机译:结论在人类肾脏疾病的过程中,肾PTH / PTHrP受体mRNA的下调发生的时间比肾功能,血浆PTH,血清磷和钙的变化要早得多。目的探讨除慢性肾脏病外,肾副甲状腺激素/甲状旁腺激素相关蛋白(PTH / PTHrP)受体信使核糖核酸(mRNA)表达的下调是否是一种普遍现象失败。

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