Establishment of an animal model of chronic atrophic gastritis and a study on the factors inducing atrophy

摘要

Conclusion Sixty percent of alcohol, 20 mmo/L sodium deoxycholate, 0.05/100-0.1/100 ammonia water and 0.05/100 indomethacin given to Sprague-Dawley rats for 6 months can successfully establish the animal model of CAG. Prolongation of the model-establishment time is not able to further facilitate the atrophy of gastric mucosa. Objective To establish a rat model of chronic atrophic gastritis and explore the factors inducing atrophy. Methods In accordance with repeated orthogonal design of L_8(2~7), 60/100 alcohol and 20 mmo/L sodium Deoxycholate(served as factor A), 0.05/100-0.1/100 ammonia water(factor B), 0.05/100 indomethacin (factor C) were given, alone or in combination, to rats in three experiments for 3 months, 6 months or 9 Months respectively.