Role of the area postrema of medulla oblongata in the regulation of canine interdigestive mirating motor complex

摘要

Conclusions The area postrema might play an important role, which is mediated by motion, on the regulation of interdigestive MMC. Objective To determine the effect of the area postrema(AP)of the medulla oblongata on gastrointestinal Interdigestive migrating motor complex(MMC)and the plasma motilin level. Methods Interdigestive MMC activities of the antrum and duodenum were recorded by strain gauge Implanted on the serosa of 8 conscious dogs. A cannula was intubated in femoral vein for motilion injection. The plasma motilin concentration was measured by RIA. We observed:(1)normal interdigestive MMC Activity and fluctuations in plasma motilin concentration;(2)the effects of electrically damaging the AP on MMC activity and plasma motilin level;(3)whether intravenous injection of motilin could induce phaseⅢ Contractions after the AP was destroyed.