PREPARATION AND ADSORBABILITY OF DEXTRAN MICROSPHERES WITH UNIFORM DIAMETER

摘要

The method of preparing uniform dextran microspheres with a narrow diameter distribution was introduced and the adsorbability of these microspheres was evaluated. The microspheres were prepared in W/O microemulsion using 0.5% dextran solution as the aqueous phase and n-hexane as the oil phase. Characteristics of the prepared dextran microspheres were examined with laser light blocking technique, optical microscope and ultraviolet spectrometer. The results show that the prepared dextran microspheres have uniform morphology and narrow diameter distribution, nearly 92% of them having a diameter of 56.6 μm. In vitro evaluation of adsorbability, wet dextran microspheres have good adsorption of 98.32 mg/g of model drug methylene blue in 20.86 mg/L methylene blue solution at 25℃. The adsorption of dried dextran microspheres under the same condition is 132.15 mg/g, which is even higher. And the adsorbability of dextran microspheres has significant relationship with the concentration of methylene blue and temperature. The adsorbability is better at lower temperature and higher concentration of methylene blue.