Study on Therapeutic Mechanism of Xilei Powder for Peptic Ulcer

摘要

One hundred and twenty-eight patients with active peptic ulcer were treated with Xilei powder for 4 weeks, their PGE_2 levels in both serum and gastro-duodenal mucosa were significantly higher than those before treatment (P < 0.01). The rate of negative conversion of Helicobacter pylori (HP) showed in 63.3% of cases. The distributed density of HP significantly reduced ( P < 0.01) . These results indicated that Xilei powder could heal ulcer probably owing to the increasing of the PGE_2 level in gastro-duodenal mucose, and inhibiting the growth and reproduction of HP so that to eliminate the HP, but did not owing to inhibit the gastric acid secretion and the release of gastrin.