Synthesis of Benzo [a] phenoxazin-5-one Derivatives and Their Interactions with DNA

摘要

The spectroscopic properties of benzo [a] phenoxazin-5-one derivatives (3a―3m) including newly synthesized 3k―3m from 4-nitrosoaniline hydrochlorides and ethyl 1, 3-dihydroxy-2-na-phthoate were studied. Compound 31 was converted into a co-valent product with DNA, which had a blue shift of the fluorescence maximum. Compounds 3a―3k were found to undergo interaction with DNA and their complexes with DNA had a red shift of the fluorescence maximum and showed increasing melting temperature of DNA. Compound 3m-DNA had a blue shift of the fluorescence maximum to 3m and showed decreasing melting temperature of DNA.