Synthesis and Pharmacological Evaluation of Some Novel Imidazo[2,1-b][1,3,4]thiadiazole Derivatives

摘要

AbstractSynthesis of bis-1,3-{6′-arylimidazo[2,1-b][1,3,4]thiadiazol-2-yl}-1,2,2-trimethylcyclopentane (3), bis-1,3-{thiadiazolo[2′,3′:2,1]imidazo[4,5-b]quinoxalinyl}-1,2,2-trimethylcyclopentane (5) has been achieved by the reaction of bis-(5′-amino-1′,3′,4′-thiadiazolyl)-1,2,2-trimethylcyclopentane with -haloketones, 2,3-dichloroquinoxaline respectively. Bromination of compound 3 furnished bis-1,3-{5′-bromo-6′-arylimidazo[2,1-b][1,3,4]thiadiazol-2-yl}-1,2,2-trimethylcyclopentane (4). The structural assignment of these compounds was supported by IR, 1H NMR and elemental analysis data. The antimicrobial, anti-inflammatory and antifungal activities of some of the compounds have also been evaluated.