1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU) Catalyzed Regiospecific and Diastereoselective Reaction of Chiral N-(tert-Butanesulfinyl)ketimines and ,β-Unsaturated Trifluoromethyl Ketones

摘要

The reaction of chiral N-(tert-butanesulfinyl)ketimines and ,β-unsaturated trifluoromethyl ketones catalyzed by DBU was achieved under mild conditions. 1,2-Addition products, precursors of chiral trifluoromethylated 1,3-amino alcohols, were obtained diastereoselectively (dr value up to 95:5) in moderate yields (up to 76%). A possible catalytic cycle was proposed.