Analsyis of T cell clonality by CDR3 size of T-cell Antigen receptor vβ repertoire in hcl and c-all

摘要

Objective: To analyze the distribution and clonality of TCR Vβ subfamily T cells in hairy cell leukemia (HCL) and Common-acute lymphoblastic leukemia (c-ALL). Methods: Peripheral blood mononuclear cell samples form 3 cases of HCL and 1 case of c-ALL were investigated for analysis of Complementarity determining region 3 (CDR3) size of T cell Receptor Vβ repertoire using reverse transcriptase- Polymerase chain reaction (RT-PCR).