Relationship between the Expression of E-cadherin and Microvessel Density in Lung Cancer and Its Significance

摘要

To study the relationship between the expression of E-cadherin and microvessel density (MVD) in lung cancer. Methods: The expression of E-cadherin and factor VIII was detected in 104 lung cancer tissues by an immunohistochemical method, and MVD was calculated by an image-analysis system. Results: The expression of E-cadherin was significantly related to the differentiation of lung cancers (P < 0.05). A negative correlation was found between E-cadherin expression and MVD in lung cancer tissues (P=0.047). Conclusion: Down-expression of E-cadherin and an increase of MVD may play an important role in the invasion and metastasis of lung cancer, and may also be used as a useful marker for tumor prognosis.