Cover Picture: Dual Effect of Halides in the Stille Reaction: In Situ Halide Metathesis and Catalyst Stabilization (Chem. Eur. J. 43/2010)

摘要

Pd-catalyzed cross-coupling reactions… …are among the most powerful tools available to synthetic organic chemists to create CC bonds. Standard Pd catalysts often prove to be inefficient in more complex (“real life”) systems, resulting in low conversions and yields of the desired compound. While the cross-coupling rate is hitherto typically increased by modification of the ligand of the Pd catalyst, simple additives (e.g., halides) can also be used to accelerate the reactions as exemplified in this paper for the Stille reaction. For more details see the Full Paper by B. U. W. Maes et al. on page 12831 ff.