Highly Recyclable Chemo-/Biocatalyzed Cascade Reactions with Ionic Liquids: One-Pot Synthesis of Chiral Biaryl Alcohols

摘要

Mix and match: We report a cascade reaction sequence for the highly enantio- and diastereoselective synthesis of biaryl alcohols, employing a Suzuki coupling followed by a biocatalytic reduction in a biphasic system containing ionic liquids (ILs; see figure). We demonstrate the recyclability of the IL phase as well as the aqueous phase up to four cycles with only a negligible deactivation of reactivity and selectivity.