The First Well-Defined Silver(I)-Complex-Catalyzed Cycloaddition of Azides onto Terminal Alkynes at Room Temperature

摘要

Silver(I)-catalyzed click chemistry: Substituted 1,2,3-triazoles are versatile intermediates with an expanding array of applications. The discovery and application of a general AgI-catalyzed azide–alkyne cycloaddition reaction (AAC) leading to 1,2,3-triazoles is reported. The synthesis of a stable, well-defined AgI complex of type [AgI(L₂)(OAc)] is described, along with the unprecedented ability of this complex to promote the general Ag-AAC at room temperature (see scheme).