Rapid Access to -Alkoxy and -Amino Acid Derivatives through Safe Continuous-Flow Generation of Diazoesters

摘要

Microreactors: A highly efficient continuous-flow process has been developed for the synthesis of diazoesters from arylsulfonylhydrazones by means of in-flow Bamford–Stevens reactions. Furthermore, a range of -alkoxy and -amino acid derivatives have been prepared in excellent yields through rhodium(II)-mediated OH and NH insertions, without the need to isolate or handle the potentially hazardous diazo species (see scheme).