Self-immolative dendritic probe for direct detection of triacetone triperoxide

摘要

A new self-immolative dendritic probe directly detects triacetone triperoxide through amplification of a single cleavage event initiated by one molecule of hydrogen peroxide into multiple-release of fluorogenic end-groups.rnAmplification of molecular signals is a major requirement for the development of sensitive probes in the field of chemical sensing. Recently several new approaches have been used to increase the signal-to-noise ratio, improving the sensitivity of detection assays. For obvious reasons, particular emphasis has been placed on the development of new techniques for detection of explosives. Triacetone triperoxide (TATP) has become an illicit explosive of choice due to its straightforward synthesis using readily available precursor chemicals, acetone and hydrogen peroxide.