A palladium-mediated cascade cyclisation approach to the CDE cores of rubriflordilactone A and lancifodilactone G

摘要

Palladium-mediated cascade cyclisation reactions have been applied to the synthesis of the CDE-ring cores of two anti-HIV natural products, rubriflordilactone A and lancifodilactone G.rnLancifodilactone G (1, Fig. 1) and rubriflordilactone A (2) are two members of a growing family of natural products isolated by Sun and co-workers from Chinese herbal plants of the Schisandra genus. They are characterised by highly oxygenated, complex fused-ring architectures, and many have been found to possess anti-HIV activity (e.g. EC_(50) = 95 μg mL~(-1) for lancifodilactone G). This disease affects some 33 million people worldwide, and causes around 3 million deaths each year, yet there remains no cure.