Asymmetric bifunctional primary aminocatalysis on magnetic nanoparticles

摘要

MNP-supported chiral primary amine catalysts were developed and evaluated as asymmetric bifunctional enamine catalysts in direct aldol reaction, showing essentially unchanged activity and stereoselectivity after 11 recycles.rnAs structural and functional mimics of type I aldolases, simple chiral primary amine catalysts have been shown to be versatile enamine catalysts that attain new level of catalysis beyond the reach of classical secondary amine catalysts. However, large catalyst loadings were normally employed in order to overcome the intrinsic lower turnover of primary aminocatalysis in many of these cases. Heterogenization of primary amine catalysts would be an effective way to improve their catalytic efficiency via catalyst recovery and reuse.