In tube determination of the absolute configuration of α- and β-hydroxy acids by NMR via chiral BINOL borates

摘要

A simple NMR methodology, through the formation of chiral BINOL borates in the NMR tube, and that reunites the advantages of chiral derivatizing (CDAs) and chiral solvating agents (CSAs), is presented for the assignment of the absolute configuration of α - and β-hydroxy acids.rnThe assignment of absolute configuration of organic compounds by NMR has been addressed by two main different approaches, each having its own advantages and disadvantages: the use of (a) chiral derivatizing agents (CDAs) or (b) chiral solvating agents (CSAs).