Synthesis and cytotoxicity of a cobaltcarbonyl-alkyne enkephalin bioconjugate

摘要

A solid-phase synthesized propargyl derivative of the neuro-peptide leucine-enkephalin (Enk) reacts rapidly and quantitatively with Co_2(CO)_8 to give the Co_2(CO)_6-alkyne labeled peptide 2, which is the first organometallic peptide bioconjugate to show significant toxicity against two different tumor cell lines.