Construction of N-1H,1H-perfluoroalkylated peptide bonds

摘要

The preparation of a variety of optically pure peptides containing an N-1H,1H-perfluoroalkyl label on a selected backbone amide bond is now possible. Peptide based drugs suffer from their poor bioavailability and poor proteolytic stability. To overcome these disadvantages, several modifications have been developed, e.g. the introduction of unnatural amino acids and the use of peptidomimetics including peptoids.