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首页> 外文期刊>Chemical Communications >Intramolecular base-accelerated radical-scavenging reaction of a planar catechin derivative bearing a lysine moiety
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Intramolecular base-accelerated radical-scavenging reaction of a planar catechin derivative bearing a lysine moiety

机译：带有赖氨酸部分的平面儿茶素衍生物的分子内碱加速自由基清除反应

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摘要

A planar catechin derivative incorporating a lysine moiety was synthesized and showed ～ 400-fold increased radical-scavenging activity relative to naturally-occurring (+)-catechin.rnOxidative stress contributes to the incidence of brain dysfunction, cancer, cardiovascular diseases, and inflammation. The prevention of such diseases by using phenolic antioxidants such as flavonoids and vitamin E is receiving increasing attention.
机译：合成了含有赖氨酸部分的平面儿茶素衍生物，相对于天然存在的（+）-儿茶素，其清除自由基的活性提高了约400倍。氧化应激会导致脑功能障碍，癌症，心血管疾病和炎症的发生。通过使用类黄酮和维生素E等酚类抗氧化剂来预防此类疾病越来越受到关注。

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  • 来源
    《Chemical Communications》 |2009年第41期|6180-6182|共3页
  • 作者

    Kiyoshi Fukuhara; Ikuo Nakanishi; Kei Ohkubo; Yoshinori Obara; Ayako Tada; Kohei Imai; Akiko Ohno; Asao Nakamura; Toshihiko Ozawa; Shiro Urano; Shinichi Saito; Shunichi Fukuzumi; Kazunori Anzai; Naoki Miyata; Haruhiro Okuda;

  • 作者单位

    Division of Organic Chemistry, National Institute of Health Sciences, Setagava-ku, Tokyo 158-8501, Japan;

    Research Center for Charged Particle Therapv, National Institute of Radiological Sciences, Inage-ku, Chiba 263-8555, Japan Graduate School of Engineering, Osaka University, SORST, Japan Science and Technology Agency, Suita, Osaka 565-0871, Japan;

    Graduate School of Engineering, Osaka University, SORST, Japan Science and Technology Agency, Suita, Osaka 565-0871, Japan;

    Faculty of Science, Tokyo University of Science, Shinjuku-ku, Tokyo 158-8501, Japan;

    Department of Applied Chemistry, Shihaura Institute of Technology, 307 Fukasaku, Minuma-ku, Saitama-shi, Saitama 337-8570, Japan;

    Department of Applied Chemistry, Shihaura Institute of Technology, 307 Fukasaku, Minuma-ku, Saitama-shi, Saitama 337-8570, Japan;

    Division of Organic Chemistry, National Institute of Health Sciences, Setagava-ku, Tokyo 158-8501, Japan;

    Department of Applied Chemistry, Shihaura Institute of Technology, 307 Fukasaku, Minuma-ku, Saitama-shi, Saitama 337-8570, Japan;

    Research Center for Charged Particle Therapv, National Institute of Radiological Sciences, Inage-ku, Chiba 263-8555, Japan Yokohama College of Pharmacy, Tozuka-ku, Yokohama. Kanagama 245-0066, Japan;

    Department of Applied Chemistry, Shihaura Institute of Technology, 307 Fukasaku, Minuma-ku, Saitama-shi, Saitama 337-8570, Japan;

    Faculty of Science, Tokyo University of Science, Shinjuku-ku, Tokyo 158-8501, Japan;

    Graduate School of Engineering, Osaka University, SORST, Japan Science and Technology Agency, Suita, Osaka 565-0871, Japan;

    Research Center for Charged Particle Therapv, National Institute of Radiological Sciences, Inage-ku, Chiba 263-8555, Japan;

    Division of Organic Chemistry, National Institute of Health Sciences, Setagava-ku, Tokyo 158-8501, Japan Graduate School of Pharmaceutical Sciences, Nagoya City University, Mizuho-ku, Nagoya, Aichi 467-8603, Japan;

    Division of Organic Chemistry, National Institute of Health Sciences, Setagava-ku, Tokyo 158-8501, Japan;

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  • 入库时间 2022-08-17 13:25:58

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