Asymmetric meso-aziridine ring-opening reactions using a chiral zirconium catalyst

摘要

A chiral zirconium catalyst prepared from Zr(O~tBu)_4 and a chiral tridentate BINOL was found to be effective for asymmetric meso-aziridine ring-opening reactions with aniline derivatives. The N-benzhydryl group on the product obtained was easily cleaved to give the corresponding amine in high yield under reductive conditions.rnRegioselective ring-opening reactions of meso-aziridines with amines are an efficient methodology for providing chiral 1,2-diamine derivatives, which are useful building blocks for the synthesis of natural products, as well as chiral organo-catalysts and chiral ligands for enantioselective reactions.