β-Amidoaldehydes via oxazoline hydroformylation

摘要

4-Substituted oxazolines, which are readily synthesized from naturally occurring α-amino acids, are converted efficiently and stereospecifically to β-amidoaldehydes in the presence of synthesis gas and catalytic dicobalt octacarbonyl. Enantiomerically pure N-protected β-aminoaldehydes are useful building blocks for addition of β-amino functionality in a stereospecific fashion. This method has been utilized for the synthesis of β-peptide derivatives as well as other bioactive molecules.