Fluoride protects boronic acids in the copper(I)-mediated click reaction

摘要

Fluoride has been found to protect boronic acids from copper(I)-mediated decomposition; such findings should be very useful for the preparation of boronic acid-based carbohydrate sensors and boronic acid conjugates using the copper(I)-mediated click reaction.rnIt is well known that boronic acids are very important in synthetic organic chemistry, medicinal chemistry and molecular recognition. Specifically, in synthetic chemistry, boronic acids are also very important intermediates in reactions such as the Suzuki coupling; boronic acid compounds have shown diverse biological activities and could be useful pharmaceutical agents, and in molecular recognition, boronic acids are known to form tight complexes with compounds containing the diol moiety, which can be used for chemosensor design.