Diphenylprolinol silyl ether as a catalyst in an asymmetric,catalytic and direct α-benzoyloxylation of aldehydesf

摘要

Diphenylprolinol silyl ether was found to promote asymmetric, catalytic and direct a-benzoyloxylation of aldehydes with benzoyl peroxide to afford oxidized products in good yields with excellent enantioselectivity.rnOptically active α-acyloxy- or α-hydroxy-aldehydes are important intermediates in organic synthesis. α-Oxygenation of aldehydes is one of the direct and straightforward methods for their synthesis, and there are several enantioselective and catalytic methods. For instance, the nitroso aldol reaction of aldehyde and nitrosobenzene catalyzed by proline, which has been developed independently by three groups including our group, is one of the powerful methods for the formation of α-aminoxy aldehydes, which are easily transformed into α-hydroxy aldehydes.