When Structural And Electronic Analogy Leads To Reactivity: The Unprecedented Phosphodiesterase Activity Of Vanadates

摘要

The interaction between an RNA model phosphodiester and oxovanadate complexes results in a purely hydrolytic cleavage of a phosphodiester bond under physiological pH and temperature: a comparison of the rate-pH profile with the species distribution diagram indicates that the negatively charged tetravanadate [V_4O_(12)]~(4-), which forms at toxic vanadium levels, is the hydrolytically active species.